On the 20th of January 2021, Vice President Kamala Harris was sworn in as the first Women to hold the second highest position in the government of the United States of America. A century and half have gone by since the Seneca Falls Convention where women first advanced what was then a radical notion that American women were autonomous individuals with political power. However, even now women are still achieving "firsts" in various disciplines, leadership, and industry. In this conversation we ask some trailblazing women who are firsts in their positions in institutional leadership about the experience of shattering glass ceilings and the continuing struggle to shed patriarchal systems of thinking and practice.